Gene
ano6
- ID
- ZDB-GENE-081104-64
- Name
- anoctamin 6
- Symbol
- ano6 Nomenclature History
- Previous Names
-
- si:ch73-177h5.1
- TMEM16F (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable chloride channel activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Delcourt et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16196 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20176 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30845 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33353 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40198 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40199 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ano6 | N/A | Delcourt et al., 2015 |
| MO2-ano6 | N/A | Delcourt et al., 2015 |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Scott syndrome | Alliance | Scott syndrome | 262890 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anoctamin | Anoctamin, dimerisation domain | Anoctamin, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:F1QNZ8 | InterPro | 910 | |||
| UniProtKB:A0A8M3AR51 | InterPro | 810 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-177H5 | ZFIN Curated Data | |
| Contained in | BAC | CH73-223F1 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005164462 (1) | 3040 nt | ||
| Genomic | GenBank:CU467633 (1) | 96978 nt | ||
| Polypeptide | UniProtKB:F1QNZ8 (1) | 910 aa |
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Delcourt, N., Quevedo, C., Nonne, C., Fons, P., O'Brien, D., Loyaux, D., Diez, M., Autelitano, F., Guillemot, J.C., Ferrara, P., Muriana, A., Callol, C., Hérault, J.P., Herbert, J.M., Favre, G., Bono, F. (2015) Targeted Identification of Sialoglycoproteins in Hypoxic Endothelial Cells and Validation in Zebrafish Reveal Roles for Proteins in Angiogenesis. The Journal of biological chemistry. 290(6):3405-17
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 3 of 3
Show