Gene
cacna1ea
- ID
- ZDB-GENE-081104-526
- Name
- calcium channel, voltage-dependent, R type, alpha 1E subunit a
- Symbol
- cacna1ea Nomenclature History
- Previous Names
-
- cacna1r
- cacna1rea
- si:dkey-21p1.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane and chemical synaptic transmission. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in neuronal cell body. Is expressed in atrium and cardiac ventricle.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 69 | Alliance | Developmental and epileptic encephalopathy 69 | 618285 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
| Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
| Family | IPR050599 | Voltage-dependent calcium channel alpha-1 subunit |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Voltage-dependent calcium channel alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TTV4 | InterPro | 2188 | ||||||
| UniProtKB:A0AB32TTW3 | InterPro | 2149 | ||||||
| UniProtKB:A0AB32TX69 | InterPro | 2149 | ||||||
| UniProtKB:A0A8M6YZX9 | InterPro | 2192 | ||||||
| UniProtKB:A0A8M6Z7T0 | InterPro | 2188 | ||||||
| UniProtKB:A0A8M6Z865 | InterPro | 2192 | ||||||
| UniProtKB:A0A8M9PR96 | InterPro | 2149 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1e-203
(1)
|
Ensembl | 5,382 nt | ||
| mRNA |
cacna1ea-202
(1)
|
Ensembl | 2,224 nt | ||
| mRNA |
cacna1ea-203
(1)
|
Ensembl | 2,547 nt |
Interactions and Pathways
No data available
Plasmids
No data available