Gene
fap
- ID
- ZDB-GENE-081104-439
- Name
- fibroblast activation protein, alpha
- Symbol
- fap Nomenclature History
- Previous Names
-
- si:dkey-81j5.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including DPP4 (dipeptidyl peptidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wei et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wei et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR002471 | Peptidase S9, serine active site |
| Domain | IPR001375 | Peptidase S9, prolyl oligopeptidase, catalytic domain |
| Domain | IPR002469 | Dipeptidylpeptidase IV, N-terminal domain |
| Domain | IPR040522 | Dipeptidyl peptidase 4, low complexity region |
| Family | IPR050278 | Serine protease S9B/DPPIV |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Dipeptidyl peptidase 4, low complexity region | Dipeptidylpeptidase IV, N-terminal domain | Peptidase S9, prolyl oligopeptidase, catalytic domain | Peptidase S9, serine active site | Serine protease S9B/DPPIV |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B0R1C4
|
750 |
Interactions and Pathways
No data available
Plasmids
No data available