Gene
nemp2
- ID
- ZDB-GENE-081104-413
- Name
- nuclear envelope integral membrane protein 2
- Symbol
- nemp2 Nomenclature History
- Previous Names
-
- loc100131211 (1)
- si:dkey-42h23.3
- tmem194b
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Acts upstream of or within oocyte maturation. Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. Is expressed in ovary. Orthologous to human NEMP2 (nuclear envelope integral membrane protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tsatskis et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tsatskis et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hsc100 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hsc101 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la016589Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019358 | NEMP family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NEMP family |
|---|---|---|---|
| UniProtKB:A0A8N7TDG6 | InterPro | 479 | |
| UniProtKB:F1QYC4 | InterPro | 479 | |
| UniProtKB:A0AB13ABK3 | InterPro | 479 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-42H23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423789 (1) | 3820 nt | ||
| Genomic | GenBank:CR735121 (1) | 114991 nt | ||
| Polypeptide | UniProtKB:A0A8N7TDG6 (1) | 479 aa |
- Tsatskis, Y., Rosenfeld, R., Pearson, J.D., Boswell, C., Qu, Y., Kim, K., Fabian, L., Mohammad, A., Wang, X., Robson, M.I., Krchma, K., Wu, J., Gonçalves, J., Hodzic, D., Wu, S., Potter, D., Pelletier, L., Dunham, W.H., Gingras, A.C., Sun, Y., Meng, J., Godt, D., Schedl, T., Ciruna, B., Choi, K., Perry, J.R.B., Bremner, R., Schirmer, E.C., Brill, J.A., Jurisicova, A., McNeill, H. (2020) The NEMP family supports metazoan fertility and nuclear envelope stiffness. Science advances. 6:eabb4591
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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