Gene
cenph
- ID
- ZDB-GENE-081104-340
- Name
- centromere protein H
- Symbol
- cenph Nomenclature History
- Previous Names
-
- si:dkey-186m8.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable kinetochore binding activity. Acts upstream of or within chromosome segregation and mitotic spindle organization. Predicted to be located in chromosome, centromeric region. Predicted to be active in kinetochore and nucleus. Is expressed in head. Orthologous to human CENPH (centromere protein H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Zhao et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zhao et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| tsu055Gt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cenph | N/A | Zhao et al., 2010 |
| MO2-cenph | N/A | Zhao et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Centromere protein H | Centromere protein H, C-terminal |
|---|---|---|---|---|
| UniProtKB:A8WHV8 | InterPro | 233 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-186M8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-190G11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113609 (1) | 702 nt | ||
| Genomic | RefSeq:NW_018395270 (1) | 440426 nt | ||
| Polypeptide | UniProtKB:A8WHV8 (1) | 233 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, X., Zhao, L., Tian, T., Zhang, Y., Tong, J., Zheng, X., and Meng, A. (2010) Interruption of cenph causes mitotic failure and embryonic death and its haploinsufficiency suppresses cancer in zebrafish. The Journal of biological chemistry. 285(36):27924-27934
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