Gene
foxp3b
- ID
- ZDB-GENE-081104-332
- Name
- forkhead box P3b
- Symbol
- foxp3b Nomenclature History
- Previous Names
-
- si:dkey-16n15.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Is expressed in head kidney and testis. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh317 | Allele with one point mutation | Unknown | Unknown | ENU | |
| foxp3b_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| ihb563 | Allele with one insertion | Unknown | Unknown | CRISPR |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome | Alliance | Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked | 304790 |
1 - 1 of 1
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp3b-201
(1)
|
Ensembl | 2,051 nt | ||
| mRNA |
foxp3b-202
(1)
|
Ensembl | 1,131 nt | ||
| mRNA |
foxp3b-203
(1)
|
Ensembl | 2,139 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16N15 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068223144 (1) | 1282 nt | ||
| Genomic | GenBank:BX005340 (1) | 119181 nt | ||
| Polypeptide | RefSeq:XP_068079245 (1) |
- Zhao, X., Liu, Y., Xie, J., Zhang, L., Zhu, Q., Su, L., Guo, C., Li, H., Wang, G., Zhang, W., Cheng, Y., Wu, N., Xia, X.Q. (2023) The manipulation of cell suspensions from zebrafish intestinal mucosa contributes to understanding enteritis. Frontiers in immunology. 14:11939771193977
- Pharkjaksu, S., Boonmee, N., Mitrpant, C., Ngamskulrungroj, P. (2021) Immunopathogenesis of Emerging Candida auris and Candida haemulonii Strains. Journal of fungi (Basel, Switzerland). 7(9):
- Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y., Zhang, Y.A. (2020) A critical role of foxp3a-positive regulatory T cells in maintaining immune homeostasis in zebrafish testis development. Journal of genetics and genomics = Yi chuan xue bao. 47(9):547-561
- Hui, S.P., Sheng, D.Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., Kikuchi, K. (2017) Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Developmental Cell. 43:659-672.e5
- Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
- Sugimoto, K., Hui, S.P., Sheng, D.Z., Nakayama, M., Kikuchi, K. (2017) Zebrafish FOXP3 is required for the maintenance of immune tolerance. Developmental and comparative immunology. 73:156-162
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
1 - 7 of 7
Show