ZFIN is now using GRCz12tu for Genomic Data
Gene
foxp3b
- ID
- ZDB-GENE-081104-332
- Name
- forkhead box P3b
- Symbol
- foxp3b Nomenclature History
- Previous Names
-
- si:dkey-16n15.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal gross anatomical part developmental process and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in head kidney and testis. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease (multiple); colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome | Alliance | Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked | 304790 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR032354 | FOXP, coiled-coil domain |
| Domain | IPR047413 | Forkhead box protein P3, forkhead domain |
| Family | IPR050998 | Forkhead box protein P |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein P | Forkhead box protein P3, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32U0M9 | InterPro | 394 | ||||||||
| UniProtKB:A0AC58G9P9 | InterPro | 494 | ||||||||
| UniProtKB:A0AC58G9Q5 | InterPro | 464 | ||||||||
| UniProtKB:A0AC58G9Q8 | InterPro | 430 | ||||||||
| UniProtKB:A0AC58G9R0 | InterPro | 456 | ||||||||
| UniProtKB:A0AC58G9V0 | InterPro | 468 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp3b-201
(1)
|
Ensembl | 2,051 nt | ||
| mRNA |
foxp3b-202
(1)
|
Ensembl | 1,131 nt | ||
| mRNA |
foxp3b-203
(1)
|
Ensembl | 2,139 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers