Gene

wsb2

ID

ZDB-GENE-081104-26

Name

WD repeat and SOCS box containing 2

Symbol

wsb2 Nomenclature History

Previous Names

si:ch73-263f13.4

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human WSB2 (WD repeat and SOCS box containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa181	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa10108	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20354	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

1 - 3 of 3

Show

Sequence Targeting Reagents

No data available

Human Disease

Associated With wsb2 Human Ortholog

No data available

Associated With wsb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001496	SOCS box domain
Family	IPR051983	WD repeat and SOCS box domain-containing protein
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036036	SOCS box-like domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Additional Resources	Length	Quinoprotein alcohol dehydrogenase-like superfamily	SOCS box domain	SOCS box-like domain superfamily	WD40 repeat	WD40 repeat, conserved site	WD40/YVTN repeat-like-containing domain superfamily	WD repeat and SOCS box domain-containing protein
UniProtKB:B8JKT2	InterPro	406
UniProtKB:A0A8M6YY44	InterPro	405

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 5

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	wsb2-201 (1) Ensembl	Ensembl		1,523 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-263F13	CU207223	ZFIN Curated Data

1 - 1 of 1

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001243384 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CT030218 (1)	117880 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B8JKT2 (1)	406 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	WSB2	12	Ensembl:ENSG00000176871 Gene:55884 HGNC:19222	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Wsb2	5	Ensembl:ENSMUSG00000029364 Gene:59043 MGI:2144041	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

1 - 1 of 1

Show