Gene

pex6

ID

ZDB-GENE-081104-252

Name

peroxisomal biogenesis factor 6

Symbol

pex6 Nomenclature History

Previous Names

si:ch73-197b13.2
si:ch73-197b13.3

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have ATPase activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to localize to cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 2; peroxisomal biogenesis disorder; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pex6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Heimler syndrome 2	Alliance	Heimler syndrome 2	616617
peroxisome biogenesis disorder 4A	Alliance	Peroxisome biogenesis disorder 4A (Zellweger)	614862
Peroxisome biogenesis disorder 4B	Alliance	Peroxisome biogenesis disorder 4B	614863

Associated With pex6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Domain	IPR047533	Peroxisomal biogenesis factor 6, second ATPase domain
Family	IPR050168	AAA ATPase domain-containing protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	AAA ATPase domain-containing protein	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	Peroxisomal biogenesis factor 6, second ATPase domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QMB0 InterPro	1071
UniProtKB:A0A8M9PSM5 InterPro	564
UniProtKB:A0A8M9P4U9 InterPro	507

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pex6-201 (1) Ensembl	Ensembl		3,216 nt	Select Tool ZFIN BLAST
mRNA	pex6-202 (1) Ensembl	Ensembl		3,562 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations