Gene

pex6

ID
ZDB-GENE-081104-252
Name
peroxisomal biogenesis factor 6
Symbol
pex6 Nomenclature History
Previous Names
  • si:ch73-197b13.2
  • si:ch73-197b13.3
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable ATP hydrolysis activity. Predicted to be involved in protein import into peroxisome matrix and protein unfolding. Predicted to act upstream of or within peroxisome organization. Predicted to be located in membrane and peroxisome. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 2; Peroxisome biogenesis disorder 4B; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa43884Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
1 - 1 of 1
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Sequence Targeting Reagents
No data available
Human Disease
Associated With pex6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Heimler syndrome 2 Alliance Heimler syndrome 2 616617
peroxisome biogenesis disorder 4A Alliance Peroxisome biogenesis disorder 4A (Zellweger) 614862
Peroxisome biogenesis disorder 4B Alliance Peroxisome biogenesis disorder 4B 614863
1 - 3 of 3
Associated With pex6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003960 ATPase, AAA-type, conserved site
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR041569 AAA ATPase, AAA+ lid domain
Domain IPR047533 Peroxisomal biogenesis factor 6, second ATPase domain
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length AAA ATPase, AAA+ lid domain AAA+ ATPase domain AAA ATPase domain-containing protein ATPase, AAA-type, conserved site ATPase, AAA-type, core Peroxisomal biogenesis factor 6, second ATPase domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QMB0 InterPro 1071
UniProtKB:A0A8M9PSM5 InterPro 564
UniProtKB:A0A8M9P4U9 InterPro 507
1 - 3 of 3
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pex6-201 (1)
Ensembl
Ensembl 3,216 nt
ZFIN BLAST
mRNA pex6-202 (1)
Ensembl
Ensembl 3,562 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-197B13ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_001332616 (1)3784 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CU469387 (1)67580 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:F1QMB0 (1)1071 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPEX66
Amino acid sequence comparison (1)
MousePex617
Amino acid sequence comparison (1)
Citations
TSV
1 - 2 of 2
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