Gene

fdft1

ID
ZDB-GENE-081104-242
Name
farnesyl-diphosphate farnesyltransferase 1
Symbol
fdft1 Nomenclature History
Previous Names
  • si:ch73-107c13.2
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have farnesyl-diphosphate farnesyltransferase activity and squalene synthase activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to localize to endoplasmic reticulum membrane. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from DeRossi et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fdft1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Squalene synthase deficiency 618156
Associated With fdft1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019845 Squalene/phytoene synthase, conserved site
Domain IPR033904 Trans-isoprenyl diphosphate synthases, head-to-head
Family IPR002060 Squalene/phytoene synthase
Family IPR006449 Squalene synthase-like
Family IPR044844 Trans-isoprenyl diphosphate synthases, eukaryotic-type
Homologous_superfamily IPR008949 Isoprenoid synthase domain superfamily
Domain Details Per Protein
Protein Length Isoprenoid synthase domain superfamily Squalene/phytoene synthase Squalene/phytoene synthase, conserved site Squalene synthase-like Trans-isoprenyl diphosphate synthases, eukaryotic-type Trans-isoprenyl diphosphate synthases, head-to-head
UniProtKB:A0A0R4IIV0 179
UniProtKB:A0A0R4IVV5 418
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations