Gene
si:dkey-172j4.3
- ID
- ZDB-GENE-081104-24
- Name
- si:dkey-172j4.3
- Symbol
- si:dkey-172j4.3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within lipid metabolic process; phosphorylation; and signal transduction. Predicted to be active in plasma membrane. Orthologous to human DGKD (diacylglycerol kinase delta) and DGKH (diacylglycerol kinase eta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016038Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11908 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18053 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31567 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34055 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38605 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40878 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000756 | Diacylglycerol kinase, accessory domain |
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR054474 | Diacylglycerol kinase eta/delta/kappa, helical domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Diacylglycerol kinase | Diacylglycerol kinase, accessory domain | Diacylglycerol kinase, catalytic domain | Diacylglycerol kinase eta/delta/kappa, helical domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | NAD kinase/diacylglycerol kinase-like domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3BAY3 | InterPro | 1100 | ||||||||||
| UniProtKB:F1R561 | InterPro | 1074 | ||||||||||
| UniProtKB:A0A8M2BJQ6 | InterPro | 1074 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-172j4.3-201
(1)
|
Ensembl | 5,088 nt | ||
| mRNA |
si:dkey-172j4.3-202
(1)
|
Ensembl | 945 nt | ||
| mRNA |
si:dkey-172j4.3-203
(1)
|
Ensembl | 3,284 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-348M15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-24G18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-172J4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005172316 (1) | 5091 nt | ||
| Genomic | GenBank:CR318658 (1) | 183287 nt | ||
| Polypeptide | UniProtKB:A0A8M3BAY3 (1) | 1100 aa |
No data available
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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