Gene
cyp3c2
- ID
- ZDB-GENE-081103-62
- Name
- cytochrome P450, family 3, subfamily c, polypeptide 2
- Symbol
- cyp3c2 Nomenclature History
- Previous Names
-
- si:dkey-21n8.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including heart; liver; male organism; nervous system; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450 3A | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QEE5 | InterPro | 503 | |||||
| UniProtKB:A0A8M6Z545 | InterPro | 268 | |||||
| UniProtKB:A0AB32TL13 | InterPro | 443 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp3c3-202
(1)
|
Ensembl | 1,449 nt | ||
| mRNA |
cyp3c3-203
(1)
|
Ensembl | 1,580 nt | ||
| ncRNA |
cyp3c2-002
(1)
|
Ensembl | 533 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21N8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068219341 (1) | 1513 nt | ||
| Genomic | GenBank:BX649536 (1) | 203180 nt | ||
| Polypeptide | UniProtKB:E9QEE5 (1) | 503 aa |
No data available
- Moreno Traspas, R., Teoh, T.S., Wong, P.M., Maier, M., Chia, C.Y., Lay, K., Ali, N.A., Larson, A., Al Mutairi, F., Al-Sannaa, N.A., Faqeih, E.A., Alfadhel, M., Cheema, H.A., Dupont, J., Bézieau, S., Isidor, B., Low, D.Y., Wang, Y., Tan, G., Lai, P.S., Piloquet, H., Joubert, M., Kayserili, H., Kripps, K.A., Nahas, S.A., Wartchow, E.P., Warren, M., Bhavani, G.S., Dasouki, M., Sandoval, R., Carvalho, E., Ramos, L., Porta, G., Wu, B., Lashkari, H.P., AlSaleem, B., BaAbbad, R.M., Abreu Ferrão, A.N., Karageorgou, V., Ordonez-Herrera, N., Khan, S., Bauer, P., Cogne, B., Bertoli-Avella, A.M., Vincent, M., Girisha, K.M., Reversade, B. (2022) Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis. Nature Genetics. 54(8):1214-1226
- Wang, J., Jia, B., Li, Y., Ren, B., Liang, H., Yan, D., Xie, H., Zhang, X., Liang, H. (2020) Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio). Journal of hazardous materials. 397:122724
- Shaya, L., Jones, D.E., Wilson, J.Y. (2018) CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Toxicology and applied pharmacology. 362:77-85
- Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shaya, L., Dejong, C., Wilson, J.Y. (2014) Expression Patterns of Cytochrome P450 3B and 3C Genes in Model Fish Species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 166:115-25
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