Gene

impg2b

ID

ZDB-GENE-081031-56

Name

interphotoreceptor matrix proteoglycan 2b

Symbol

impg2b Nomenclature History

Previous Names

impg2
si:ch211-213c4.2
si:ch211-239j15.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable heparin binding activity and hyaluronic acid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within visual perception. Predicted to be located in several cellular components, including cell projection; extracellular region; and interphotoreceptor matrix. Human ortholog(s) of this gene implicated in retinitis pigmentosa 56 and vitelliform macular dystrophy. Orthologous to human IMPG2 (interphotoreceptor matrix proteoglycan 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Castellini et al., 2023

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With impg2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 56	Alliance	Retinitis pigmentosa 56	613581
vitelliform macular dystrophy	Alliance	Macular dystrophy, vitelliform, 5	616152

Associated With impg2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000082	SEA domain
Domain	IPR000742	EGF-like domain
Family	IPR039861	Interphotoreceptor matrix proteoglycan
Homologous_superfamily	IPR036364	SEA domain superfamily

Domain Details Per Protein

Protein	Length	EGF-like domain	Interphotoreceptor matrix proteoglycan	SEA domain	SEA domain superfamily
UniProtKB:A0A8M9Q584 InterPro	2779
UniProtKB:A0A8M3B5Q4 InterPro	2821
UniProtKB:A0A8M9Q3E3 InterPro	2810
UniProtKB:A0A8M9PQB5 InterPro	2779

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	impg2b-201 (1) Ensembl	Ensembl	278 nt	Select Tool ZFIN BLAST
mRNA	impg2b-202 (1) Ensembl	Ensembl	1,061 nt	Select Tool ZFIN BLAST
mRNA	impg2b-203 (1) Ensembl	Ensembl	475 nt	Select Tool ZFIN BLAST
mRNA	impg2b-204 (1) Ensembl	Ensembl	1,287 nt	Select Tool ZFIN BLAST
mRNA	impg2b-205 (1) Ensembl	Ensembl	274 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations