Gene
trpc6b
- ID
- ZDB-GENE-081030-19
- Name
- transient receptor potential cation channel, subfamily C, member 6b
- Symbol
- trpc6b Nomenclature History
- Previous Names
-
- si:dkey-20h16.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Is expressed in trigeminal motor nucleus. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from von Niederhäusern et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 2 | Alliance | Glomerulosclerosis, focal segmental, 2 | 603965 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RKV1
|
858 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
trpc6b-201
(1)
|
Havana | 2923 nt |
Interactions and Pathways
No data available
Plasmids
No data available