Gene
tbxtb
- ID
- ZDB-GENE-081028-48
- Name
- T-box transcription factor Tb
- Symbol
- tbxtb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including mesoderm formation; regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in margin; mesoderm; notochord; tail bud; and ventral mesoderm. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Martin et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tbxtb | Saunders et al., 2023 | |
| CRISPR2-tbxtb | Saunders et al., 2023 | |
| CRISPR3-tbxtb | Saunders et al., 2023 | |
| MO1-tbxtb | N/A | Martin et al., 2008 |
| MO2-tbxtb | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Family | IPR002070 | Transcription factor, Brachyury |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, Brachyury | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WGE3 | InterPro | 424 | ||||||
| UniProtKB:A0A8M3BEG1 | InterPro | 415 | ||||||
| UniProtKB:A0A8M3AYT2 | InterPro | 356 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-130H14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001343597 (1) | 2048 nt | ||
| Genomic | GenBank:CR854838 (1) | 148487 nt | ||
| Polypeptide | UniProtKB:X1WGE3 (1) | 424 aa |
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):
- Peng, L., Zhou, Y., Xu, W., Jiang, M., Li, H., Long, M., Liu, W., Liu, J., Zhao, X., Xiao, Y. (2019) Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts. International journal of biological sciences. 15:2340-2349
- Rhyu, D., Lee, H., Tanguay, R.L., Kim, K.T. (2019) Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) disrupts zebrafish tail fin development. Ecotoxicology and environmental safety. 182:109449
- Nelson, A.C., Cutty, S.J., Gasiunas, S.N., Deplae, I., Stemple, D.L., Wardle, F.C. (2017) In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors. Cell Reports. 19:2782-2795
- Reeves, W.M., Wu, Y., Harder, M.J., Veeman, M.T. (2017) Functional and evolutionary insights from the Ciona notochord transcriptome.. Development (Cambridge, England). 144:3375-3387
- Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41
- Kimelman, D. (2016) A novel cold-sensitive mutant of ntla reveals temporal roles of Brachyury in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 245(8):874-80
- Bouldin, C.M., Manning, A.J., Peng, Y.H., Farr, G.H., Hung, K.L., Dong, A., Kimelman, D. (2015) Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development (Cambridge, England). 142:2499-507
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