Gene

plekhh2

ID

ZDB-GENE-081028-42

Name

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

Symbol

plekhh2 Nomenclature History

Previous Names

si:ch73-105b23.3

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable actin binding activity. Predicted to be involved in negative regulation of actin filament depolymerization. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plekhh2 Human Ortholog

No data available

Associated With plekhh2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000299	FERM domain
Domain	IPR000857	MyTH4 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR038185	MyTH4 domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	MyTH4 domain	MyTH4 domain superfamily	PH-like domain superfamily	Pleckstrin homology domain
UniProtKB:A0A8M9QFR0 InterPro	1423

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	plekhh2-201 (1) Ensembl	Ensembl		4,146 nt	Select Tool ZFIN BLAST
mRNA	plekhh2-202 (1) Ensembl	Ensembl		5,344 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations