Gene
htr1b
- ID
- ZDB-GENE-081022-141
- Name
- 5-hydroxytryptamine (serotonin) receptor 1B
- Symbol
- htr1b Nomenclature History
- Previous Names
-
- zgc:194666
- zgc:194690
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within several processes, including bone remodeling; regulation of behavior; and vasoconstriction. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in central nervous system; male organism; pharynx; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-Hydroxytryptamine 1B receptor | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:B3DK14 | InterPro | 380 |
Interactions and Pathways
No data available
Plasmids
No data available