Gene
nsmce2
- ID
- ZDB-GENE-081022-128
- Name
- NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
- Symbol
- nsmce2 Nomenclature History
- Previous Names
-
- zgc:194590
- zgc:194609
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have SUMO transferase activity and zinc ion binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to localize to Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Payne et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Seckel syndrome 10 | Alliance | Seckel syndrome 10 | 617253 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E3 SUMO-protein ligase Nse2 (Mms21) | Zinc finger, MIZ-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|
|
UniProtKB:B3DIX8
|
230 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nsmce2-201
(1)
|
Ensembl | 877 nt | ||
| mRNA |
nsmce2-202
(1)
|
Ensembl | 752 nt |
Interactions and Pathways
No data available
Plasmids
No data available