Gene
zbtb24
- ID
- ZDB-GENE-081022-123
- Name
- zinc finger and BTB domain containing 24
- Symbol
- zbtb24 Nomenclature History
- Previous Names
-
- zgc:194556
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rajshekar et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zbtb24 | N/A | Huang et al., 2013 |
| MO2-zbtb24 | N/A | Calvird et al., 2022 |
| TALEN1-zbtb24 | Rajshekar et al., 2018 | |
| TALEN2-zbtb24 | Rajshekar et al., 2018 | |
| TALEN3-zbtb24 | Rajshekar et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome 2 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 2 | 614069 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome | zbtb24mk22/mk22 | standard conditions | Rajshekar et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | SKP1/BTB/POZ domain superfamily | Zinc finger and BTB domain-containing | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein, C2H2-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q52KB5 | InterPro | 672 | ||||||
| UniProtKB:E7F443 | InterPro | 678 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zbtb24-201
(1)
|
Ensembl | 4,805 nt | ||
| mRNA |
zbtb24-202
(1)
|
Ensembl | 2,088 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-242M19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194556 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001023572 (1) | 4830 nt | ||
| Genomic | GenBank:BX936450 (1) | 167918 nt | ||
| Polypeptide | UniProtKB:E7F443 (1) | 678 aa |
- Calvird, A.E., Broniec, M.N., Duval, K.L., Higgs, A.N., Arora, V., Ha, L.N., Schouten, E.B., Crippen, A.R., McGrail, M., Laue, K., Goll, M.G. (2022) Uncovering Regulators of Heterochromatin Mediated Silencing Using a Zebrafish Transgenic Reporter. Frontiers in cell and developmental biology. 10:832461
- Gao, L., Yuan, Z., Zhou, T., Yang, Y., Gao, D., Dunham, R., Liu, Z. (2019) FOXO genes in channel catfish and their response after bacterial infection. Developmental and comparative immunology. 97:38-44
- Rajshekar, S., Yao, J., Arnold, P.K., Payne, S.G., Zhang, Y., Bowman, T.V., Schmitz, R.J., Edwards, J.R., Goll, M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. eLIFE. 7:
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Edgar, A.J., Dover, S.L., Lodrick, M.N., McKay, I.J., Hughes, F.J., and Turner, W. (2005) Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450. Journal of cellular biochemistry. 94(1):202-215
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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