zbtb24

ID

ZDB-GENE-081022-123

Name

zinc finger and BTB domain containing 24

Symbol

zbtb24 Nomenclature History

Previous Names

zgc:194556

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Rajshekar et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zbtb24 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 2	Alliance	Immunodeficiency-centromeric instability-facial anomalies syndrome 2	614069

Associated With zbtb24 Via Experimental Models

Human Disease	Fish	Conditions	Citations
immunodeficiency-centromeric instability-facial anomalies syndrome	zbtb24^mk22/mk22	standard conditions	Rajshekar et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050457	Zinc finger and BTB domain-containing
Family	IPR050758	Zinc finger protein, C2H2-type
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily