Gene
zbtb24
- ID
- ZDB-GENE-081022-123
- Name
- zinc finger and BTB domain containing 24
- Symbol
- zbtb24 Nomenclature History
- Previous Names
-
- zgc:194556
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rajshekar et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome 2 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 2 | 614069 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome | zbtb24mk22/mk22 | standard conditions | Rajshekar et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR050457 | Zinc finger and BTB domain-containing |
| Family | IPR050758 | Zinc finger protein, C2H2-type |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | SKP1/BTB/POZ domain superfamily | Zinc finger and BTB domain-containing | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein, C2H2-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q52KB5 | InterPro | 672 | ||||||
| UniProtKB:E7F443 | InterPro | 678 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zbtb24-201
(1)
|
Ensembl | 4,805 nt | ||
| mRNA |
zbtb24-202
(1)
|
Ensembl | 2,088 nt |
Interactions and Pathways
No data available
Plasmids
No data available