ZFIN is now using GRCz12tu for Genomic Data
Gene
cdkl5
- ID
- ZDB-GENE-081022-110
- Name
- cyclin dependent kinase like 5
- Symbol
- cdkl5 Nomenclature History
- Previous Names
-
- zgc:194395
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including neuronal action potential propagation; skeletal system development; and swimming behavior. Located in cytoplasm and nucleus. Is expressed in several structures, including fin; heart; muscle; notochord; and pleuroperitoneal region. Used to study developmental and epileptic encephalopathy. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; and intellectual disability. Orthologous to human CDKL5 (cyclin dependent kinase like 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 2 | Alliance | Developmental and epileptic encephalopathy 2 | 300672 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| developmental and epileptic encephalopathy | cdkl5sa21938/sa21938 | standard conditions | Varela et al., 2025 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:B9X2H6 | InterPro | 1080 | |||||
| UniProtKB:B3DI12 | InterPro | 1039 | |||||
| UniProtKB:A0A8M3B458 | InterPro | 887 | |||||
| UniProtKB:B9X2H5 | InterPro | 1039 | |||||
| UniProtKB:A0AB32TZ40 | InterPro | 1046 | |||||
| UniProtKB:A0AC58GQR4 | InterPro | 1080 | |||||
| UniProtKB:A0AC58GQR9 | InterPro | 1039 | |||||
| UniProtKB:A0AC58GQS0 | InterPro | 1039 | |||||
| UniProtKB:A0AC58GQS1 | InterPro | 1005 | |||||
| UniProtKB:A0AC58GQS3 | InterPro | 887 | |||||
| UniProtKB:A0AC58GQS6 | InterPro | 853 | |||||
| UniProtKB:A0AC58GQS8 | InterPro | 1039 | |||||
| UniProtKB:A0AC58GQS9 | InterPro | 887 | |||||
| UniProtKB:A0AC58GQT1 | InterPro | 1039 | |||||
| UniProtKB:A0AC58GQT6 | InterPro | 1005 | |||||
| UniProtKB:A0AC58GQU1 | InterPro | 846 | |||||
| UniProtKB:A0AC58GQU4 | InterPro | 1046 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers