Gene
prox2
- ID
- ZDB-GENE-081003-3
- Name
- prospero homeobox 2
- Symbol
- prox2 Nomenclature History
- Previous Names
-
- prox1-like (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including gonad; hindbrain neural keel; immature eye; liver; and nervous system. Orthologous to human PROX2 (prospero homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Pistocchi et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeo-prospero domain | Homeo-prospero domain superfamily | Prospero homeodomain family |
|---|---|---|---|---|---|---|
| UniProtKB:B2BHT6 | InterPro | 582 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173A9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-21D17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128292 (1) | 2435 nt | ||
| Genomic | GenBank:BX927356 (1) | 204195 nt | ||
| Polypeptide | UniProtKB:B2BHT6 (1) | 582 aa |
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
- Pistocchi, A., Bartesaghi, S., Cotelli, F., and Del Giacco, L. (2008) Identification and expression pattern of zebrafish prox2 during embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3916-3920
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