Gene

smyhc3

ID
ZDB-GENE-080930-1
Name
slow myosin heavy chain 3
Symbol
smyhc3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Predicted to be part of myosin complex. Is expressed in cephalic musculature; levator arcus palatini; superficial lateralis; and supracarinalis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smyhc3 Human Ortholog
No data available
Associated With smyhc3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A2R8Q4Q8 1934
UniProtKB:A0A2R8Q9I2 1952
UniProtKB:B6IDE0 1938
UniProtKB:A8WBZ8 1917
UniProtKB:A0A2R8QGS1 1940
UniProtKB:A8WBZ9 14
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations