Gene
pbrm1
- ID
- ZDB-GENE-080926-4
- Name
- polybromo 1
- Symbol
- pbrm1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and chromatin binding activity. Predicted to act upstream of or within chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of RSC-type complex. Is expressed in somite. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Armant et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonpapillary renal cell carcinoma | Alliance | ?Renal cell carcinoma, clear cell | 144700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR037968 | Protein polybromo-1, Bromodomain 5 |
| Family | IPR037382 | Remodelling complex subunit Rsc/polybromo |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
| Homologous_superfamily | IPR043151 | Bromo adjacent homology (BAH) domain superfamily |
Domain Details Per Protein
| Protein | Length | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | High mobility group box domain | High mobility group box domain superfamily | Protein polybromo-1, Bromodomain 5 | Remodelling complex subunit Rsc/polybromo |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F8D8
|
1627 | |||||||||
|
UniProtKB:A0A8M3B6P7
|
1559 | |||||||||
|
UniProtKB:A0A8M9QLS6
|
1582 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance