Gene

adrb3a

ID
ZDB-GENE-080917-21
Name
adrenoceptor beta 3a
Symbol
adrb3a Nomenclature History
Previous Names
  • im:7154935 (1)
  • si:ch211-215f19.1
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable beta3-adrenergic receptor activity and epinephrine binding activity. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; and positive regulation of MAPK cascade. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in blood; brain; hatching gland; intermediate cell mass of mesoderm; and polster. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adrb3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance {Obesity, susceptibility to} 601665
1 - 1 of 1
Associated With adrb3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:B0UYT9 InterPro 413
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adrb3a-201 (1)
Ensembl
Ensembl 2,024 nt
ZFIN BLAST
mRNA adrb3a-202 (1)
Ensembl
Ensembl 1,317 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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