Gene
nos2b
- ID
- ZDB-GENE-080916-1
- Name
- nitric oxide synthase 2b, inducible
- Symbol
- nos2b Nomenclature History
- Previous Names
-
- inosb
- inducible nitric oxide synthase b
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable FMN binding activity; flavin adenine dinucleotide binding activity; and nitric-oxide synthase activity. Acts upstream of or within inflammatory response to wounding; response to lipopolysaccharide; and swimming behavior. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including Kupffer's vesicle; diencephalon; digestive system; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019311Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa364 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8873 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35915 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35916 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42569 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sou2 | Allele with one deletion | Exon 9 | Frameshift, Premature Stop | CRISPR |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nos2b | (3) | |
| CRISPR2-nos2b | Yu et al., 2024 | |
| CRISPR3-nos2b | Yu et al., 2024 | |
| MO1-nos2b | N/A | Wittmann et al., 2015 |
| MO2-nos2b | N/A | (2) |
| MO3-nos2b | N/A | Rochon et al., 2023 |
1 - 6 of 6
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Malaria, resistance to} | 611162 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR004030 | Nitric oxide synthase, N-terminal |
1 - 5 of 17 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Nitric oxide synthase, domain 1 superfamily | Nitric oxide synthase, domain 2 superfamily | Nitric oxide synthase, domain 3 superfamily | Nitric-oxide synthase, eukaryote | Nitric Oxide Synthase (NOS) | Nitric oxide synthase, N-terminal | Nitric oxide synthase, N-terminal domain superfamily | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B421 | InterPro | 687 | |||||||||||||||||
| UniProtKB:A9JNR5 | InterPro | 1077 | |||||||||||||||||
| UniProtKB:A0A8M3AHD3 | InterPro | 939 | |||||||||||||||||
| UniProtKB:F1QML0 | InterPro | 1077 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-285L4 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113501 (1) | 3435 nt | ||
| Genomic | GenBank:BX649531 (2) | 185865 nt | ||
| Polypeptide | UniProtKB:A9JNR5 (1) | 1077 aa |
- Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., Bao, B. (2024) Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology. 13(6):
- Ranjan, G., Sehgal, P., Scaria, V., Sivasubbu, S. (2024) SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. EMBO reports. 25(11):4950-4978
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Rochon, E.R., Xue, J., Mohammed, M.S., Smith, C., Hay-Schmidt, A., DeMartino, A.W., Clark, A., Xu, Q., Lo, C.W., Tsang, M., Tejero, J., Gladwin, M.T., Corti, P. (2023) Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nature communications. 14:83338333
- Deng, Y., Wang, L., Wei, T., Chen, Y., Wu, X., Guo, Y., Lin, H., Tang, H., Liu, X. (2022) Inhibition of oocyte maturation by nitric oxide synthase 1 (NOS1) in zebrafish. General and comparative endocrinology. 321-322:114012
- Hariom, S.K., Nelson, E.J.R. (2022) Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish. Life sciences in space research. 34:21-29
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Kumar, J., Kumar, M., Sharma, S., Srivastava, N., Singh, R., Hussain, M.A., Mazumder, S. (2022) Th1-Th2 and M1-M2 interplay sculpt Aeromonas hydrophila pathogenesis in zebrafish (Danio rerio). Fish & shellfish immunology. 127:357-365
- Maleski, A.L.A., Rosa, J.G.S., Bernardo, J.T.G., Astray, R.M., Walker, C.I.B., Lopes-Ferreira, M., Lima, C. (2022) Recapitulation of Retinal Damage in Zebrafish Larvae Infected with Zika Virus. Cells. 11(9)
- Sahashi, D., Kubo, Y., Ishi, M., Ikeda, A., Yamasaki, C., Komatsu, M., Shiozaki, K. (2022) Neu1 deficiency increases the susceptibility of zebrafish to Edwardsiella piscicida infection via lysosomal dysfunction. Gene. 836:146667
1 - 10 of 52
Show