Gene
ca10b
- ID
- ZDB-GENE-080815-2
- Name
- carbonic anhydrase Xb
- Symbol
- ca10b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable hydro-lyase activity. Acts upstream of or within swimming behavior. Is expressed in several structures, including eye; gill; heart; integument; and pleuroperitoneal region. Orthologous to human CA10 (carbonic anhydrase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Aspatwar et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Aspatwar et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa612 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ca10b | Aspatwar et al., 2015 | |
| CRISPR2-ca10b | Aspatwar et al., 2015 | |
| MO1-ca10b | N/A | Aspatwar et al., 2015 |
| MO2-ca10b | N/A | Aspatwar et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha carbonic anhydrase domain | Alpha carbonic anhydrase domain superfamily | Carbonic anhydrase, alpha-class | Carbonic anhydrase-related protein X/XI |
|---|---|---|---|---|---|---|
| UniProtKB:E7EYF2 | InterPro | |||||
| UniProtKB:A0A0R4IB70 | InterPro | |||||
| UniProtKB:A0A8M2BBM0 | InterPro | 326 | ||||
| UniProtKB:A0AB32TPS1 | InterPro | 265 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-250G22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-15H19 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068219190 (1) | 1644 nt | ||
| Genomic | GenBank:BX890590 (1) | 141661 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBM0 (1) | 326 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Aspatwar, A., Tolvanen, M.E., Ojanen, M.J., Barker, H.R., Saralahti, A.K., Bäuerlein, C.A., Ortutay, C., Pan, P., Kuuslahti, M., Parikka, M., Rämet, M., Parkkila, S. (2015) Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish. PLoS One. 10:e0134263
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260
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