ZFIN is now using GRCz12tu for Genomic Data
Gene
hpgd
- ID
- ZDB-GENE-080728-2
- Name
- 15-hydroxyprostaglandin dehydrogenase
- Symbol
- hpgd Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Predicted to act upstream of or within prostaglandin metabolic process. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hypertrophic osteoarthropathy | Alliance | Cranioosteoarthropathy | 259100 |
| primary hypertrophic osteoarthropathy | Alliance | Hypertrophic osteoarthropathy, primary, autosomal recessive 1 | 259100 |
| ?Digital clubbing, isolated congenital | 119900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
|---|---|---|---|---|---|
| UniProtKB:E7F258 | InterPro | 261 | |||
| UniProtKB:A0A8M9QCH9 | InterPro | 203 | |||
| UniProtKB:A0A8M3AIL6 | InterPro | 187 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers