Gene
lpin1a
- ID
- ZDB-GENE-080722-2
- Name
- lipin 1a
- Symbol
- lpin1a Nomenclature History
- Previous Names
-
- lpin1
- zgc:194552
- zgc:194558
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in mitochondrial outer membrane and nucleus. Is expressed in several structures, including musculature system; optic cup; paraxial mesoderm; subcutaneous fat; and visceral fat. Orthologous to human LPIN1 (lipin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Lu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23110 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lpin1a | N/A | Manesia et al., 2017 |
| MO2-lpin1a | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myoglobinuria | Alliance | Myoglobinuria, acute recurrent, autosomal recessive | 268200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | HAD-like superfamily | LIPIN family | Lipin, middle domain | Lipin/Ned1/Smp2 (LNS2) | Lipin, N-terminal | LNS2/PITP |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DIU0
|
894 | ||||||
|
UniProtKB:X1WH54
|
920 | ||||||
|
UniProtKB:Q14EB8
|
894 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175F11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194552 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194558 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044353 (1) | 2685 nt | ||
| Genomic | GenBank:CR391932 (1) | 282174 nt | ||
| Polypeptide | UniProtKB:X1WH54 (1) | 920 aa |
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Jia, X., Feng, Y., Ma, W., Zhao, W., Liu, Y., Jing, G., Tian, J., Yang, T., Zhang, C. (2023) A fluidic platform for mobility evaluation of zebrafish with gene deficiency. Frontiers in molecular neuroscience. 16:11149281114928
- Sun, F., Ou, J., Shoffner, A.R., Luan, Y., Yang, H., Song, L., Safi, A., Cao, J., Yue, F., Crawford, G.E., Poss, K.D. (2022) Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Nature cell biology. 24(5):685-696
- Zhang, Q., Sun, S., Zhang, Y., Wang, X., Li, Q. (2022) Identification of Scd5 as a functional regulator of visceral fat deposition and distribution. iScience. 25:103916
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Chen, B., Zheng, Y.M., Zhang, J.P. (2018) Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Frontiers in endocrinology. 9:366
- Yao, Y., Sun, S., Wang, J., Fei, F., Dong, Z., Ke, A.W., He, R., Wang, L., Zhang, L., Ji, M.B., Li, Q., Yu, M., Shi, G.M., Fan, J., Gong, Z., Wang, X. (2018) Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult. Cancer research. 78(19):5548-5560
- Manesia, J.K., Franch, M., Tabas-Madrid, D., Nogales-Cadenas, R., Vanwelden, T., Van Den Bosch, E., Xu, Z., Pascual-Montano, A., Khurana, S., Verfaillie, C. (2017) Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hematopoietic stem cell function. Stem cells and development. 26(8):573-584
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