Gene
cadm2b
- ID
- ZDB-GENE-080506-3
- Name
- cell adhesion molecule 2b
- Symbol
- cadm2b Nomenclature History
- Previous Names
-
- si:ch211-220p9.1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in plasma membrane. Is expressed in eye; immature eye; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Pietri et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22591 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cadm2b | Charlton-Perkins et al., 2019 | |
| CRISPR2-cadm2b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
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Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Neurexin/syndecan/glycophorin C |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B4C0
|
396 | |||||||||
|
UniProtKB:A0A8M2B3K2
|
441 | |||||||||
|
UniProtKB:A0A8M3B0S3
|
400 | |||||||||
|
UniProtKB:B0F6R2
|
401 | |||||||||
|
UniProtKB:A0A8M2B3L3
|
440 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cadm2b-201
(1)
|
Ensembl | 1,259 nt | ||
| mRNA |
cadm2b-202
(1)
|
Ensembl | 1,119 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220P9 | ZFIN Curated Data | |
| Contained in | BAC | CH211-276A12 | ||
| Contained in | BAC | DKEY-3E1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-178C13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113555 (1) | 1206 nt | ||
| Genomic | GenBank:AL954312 (1) | 231100 nt | ||
| Polypeptide | UniProtKB:A0A8M2B3K2 (1) | 441 aa |
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
- Hunter, P.R., Nikolaou, N., Odermatt, B., Williams, P.R., Drescher, U., and Meyer, M.P. (2011) Localization of cadm2a and cadm3 proteins during development of the zebrafish nervous system. The Journal of comparative neurology. 519(11):2252-70
- Pietri, T., Easley-Neal, C., Wilson, C., and Washbourne, P. (2008) Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(1):233-246
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