Gene

hmx2

ID

ZDB-GENE-080506-2

Name

H6 family homeobox 2

Symbol

hmx2 Nomenclature History

Previous Names

nkx5.2 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within inner ear morphogenesis and posterior lateral line development. Predicted to be active in nucleus. Is expressed in nervous system; otic vesicle; and spinal cord neural tube. Orthologous to human HMX2 (H6 family homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Feng et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmx2 Human Ortholog

No data available

Associated With hmx2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR051300	HMX Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily