Gene
megf10
- ID
- ZDB-GENE-080506-1
- Name
- multiple EGF-like-domains 10
- Symbol
- megf10 Nomenclature History
- Previous Names
-
- fc33e05
- wu:fc33e05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Involved in myofibril assembly. Predicted to localize to integral component of membrane and plasma membrane. Used to study myopathy. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myopathy 10B | Alliance | Congenital myopathy 10B, mild variant | 620249 |
| early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome | Alliance | Congenital myopathy 10A, severe variant | 614399 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myopathy | megf10sa13029/sa13029 | standard conditions | Saha et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like, conserved site | EGF-like domain | EMI domain | Laminin-type EGF domain | MEGF10/SREC1/2-like |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QV85
|
1120 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
megf10-201
(1)
|
Ensembl | 3,544 nt | ||
| mRNA |
megf10-203
(1)
|
Ensembl | 3,225 nt | ||
| mRNA |
megf10-204
(1)
|
Ensembl | 3,429 nt | ||
| ncRNA |
megf10-002
(1)
|
Ensembl | 797 nt |
Interactions and Pathways
No data available
Plasmids
No data available