Gene

atp2b3b

ID

ZDB-GENE-080409-2

Name

ATPase plasma membrane Ca2+ transporting 3b

Symbol

atp2b3b Nomenclature History

Previous Names

pmca3b (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have PDZ domain binding activity and calcium transmembrane transporter activity, phosphorylative mechanism. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to localize to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Is expressed in brain and eye. Orthologous to several human genes including ATP2B3 (ATPase plasma membrane Ca2+ transporting 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liao et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp2b3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked spinocerebellar ataxia 1	Alliance	?Spinocerebellar ataxia, X-linked 1	302500

Associated With atp2b3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004014	Cation-transporting P-type ATPase, N-terminal
Domain	IPR006068	Cation-transporting P-type ATPase, C-terminal
Domain	IPR022141	Plasma membrane calcium transporting P-type ATPase, C-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Family	IPR001757	P-type ATPase
Family	IPR006408	P-type ATPase, subfamily IIB
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site

Domain Details Per Protein

Protein	Length	Cation-transporting P-type ATPase, C-terminal	Cation-transporting P-type ATPase, N-terminal	HAD-like superfamily	HAD superfamily	Plasma membrane calcium transporting P-type ATPase, C-terminal	P-type ATPase	P-type ATPase, A domain superfamily	P-type ATPase, cytoplasmic domain N	P-type ATPase, haloacid dehalogenase domain	P-type ATPase, phosphorylation site	P-type ATPase, subfamily IIB	P-type ATPase, transmembrane domain superfamily
UniProtKB:A0A8M9PWI4 InterPro	1297
UniProtKB:A0A8M3ANI2 InterPro	1259
UniProtKB:A0A8M3AY93 InterPro	1245
UniProtKB:X1WCG5 InterPro	1180
UniProtKB:A0A8M2B8Y9 InterPro	1166
UniProtKB:B2CZC0 InterPro	1174

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atp2b3b-201 (1) Ensembl	Ensembl	4,576 nt	Select Tool ZFIN BLAST
mRNA	atp2b3b-203 (1) Ensembl	Ensembl	9,347 nt	Select Tool
ncRNA	atp2b3b-002 (1) Ensembl	Ensembl	510 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations