Gene

erap2

ID

ZDB-GENE-080402-6

Name

endoplasmic reticulum aminopeptidase 2

Symbol

erap2 Nomenclature History

Previous Names

zgc:172163

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm. Orthologous to human ERAP2 (endoplasmic reticulum aminopeptidase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Gao et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erap2 Human Ortholog

No data available

Associated With erap2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR014782	Peptidase M1, membrane alanine aminopeptidase
Domain	IPR024571	ERAP1-like C-terminal domain
Domain	IPR045357	Aminopeptidase N-like , N-terminal domain
Family	IPR001930	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Family	IPR034016	Aminopeptidase N-type
Family	IPR050344	Peptidase M1 family aminopeptidases
Homologous_superfamily	IPR027268	Peptidase M4/M1, CTD superfamily
Homologous_superfamily	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy

Domain Details Per Protein

Protein	Length	Aminopeptidase N-like , N-terminal domain	Aminopeptidase N-like , N-terminal domain superfamliy	Aminopeptidase N-type	ERAP1-like C-terminal domain	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase	Peptidase M1 family aminopeptidases	Peptidase M1, membrane alanine aminopeptidase	Peptidase M4/M1, CTD superfamily
UniProtKB:B1H1J0 InterPro	931
UniProtKB:A0A8M2BCU9 InterPro	935

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	erap2-201 (1) Ensembl	Ensembl		3,225 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations