Gene

il2rgb

ID

ZDB-GENE-080402-2

Name

interleukin 2 receptor, gamma b

Symbol

il2rgb Nomenclature History

Previous Names

il2rgc.b (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have cytokine receptor activity and interleukin-2 binding activity. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Is expressed in brain; eye; liver; pleuroperitoneal region; and thymus. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il2rgb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked severe combined immunodeficiency	Alliance	Severe combined immunodeficiency, X-linked	300400
		Combined immunodeficiency, X-linked, moderate	312863

Associated With il2rgb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003531	Short hematopoietin receptor, family 1, conserved site
Domain	IPR003961	Fibronectin type III
Domain	IPR048651	Cytokine receptor-like factor 2-like, D1 domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily