Gene
flrt1b
- ID
- ZDB-GENE-080327-6
- Name
- fibronectin leucine rich transmembrane protein 1b
- Symbol
- flrt1b Nomenclature History
- Previous Names
-
- sc:d0318
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in basal plate midbrain region and nervous system. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0318 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Busch-Nentwich et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050333 | Small Leucine-Rich Proteoglycans |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Small Leucine-Rich Proteoglycans |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QF54 | InterPro | 715 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
flrt1b-201
(1)
|
Ensembl | 7,287 nt | ||
| mRNA |
flrt1b-202
(1)
|
Ensembl | 2,148 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-115C23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-119C18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-87L3 | ZFIN Curated Data | |
| Encodes | EST | cssl:d0318 | Thisse et al., 2008 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005169618 (1) | 2406 nt | ||
| Genomic | GenBank:CU855924 (1) | 153745 nt | ||
| Polypeptide | UniProtKB:F1QF54 (1) | 715 aa |
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Söllner, C., and Wright, G.J. (2009) A cell surface interaction network of neural leucine-rich repeat receptors. Genome biology. 10(9):R99
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