Gene
lrrc4cb
- ID
- ZDB-GENE-080327-5
- Name
- leucine rich repeat containing 4C, genome duplicate b
- Symbol
- lrrc4cb Nomenclature History
- Previous Names
-
- sc:d0316 (1)
- si:dkey-6l15.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in modulation of chemical synaptic transmission; regulation of axonogenesis; and synaptic membrane adhesion. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in basal plate midbrain region and nervous system. Orthologous to human LRRC4C (leucine rich repeat containing 4C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0316 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| re18 | Allele with one deletion | Unknown | Unknown | not specified | |
| sa238 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21060 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34176 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38639 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41005 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cysteine-rich flanking region, C-terminal | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QCU7
|
631 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrrc4c (1 of many)-202
(1)
|
Ensembl | 4,447 nt | ||
| mRNA |
lrrc4cb-201
(1)
|
Ensembl | 1,896 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | cssl:d0316 | Thisse et al., 2008 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005166488 (1) | 2193 nt | ||
| Genomic | GenBank:CR388018 (1) | 171808 nt | ||
| Polypeptide | UniProtKB:F1QCU7 (1) | 631 aa |
- Comparative Orthology
- Alliance
- Quint, W.H., Tadema, K.C.D., Kokke, N.C.C.J., Meester-Smoor, M.A., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2023) Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Scientific Reports. 13:20172017
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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