Gene

lrrc3

ID

ZDB-GENE-080327-13

Name

leucine rich repeat containing 3

Symbol

lrrc3 Nomenclature History

Previous Names

sc:d0333 (1)
si:dkey-253a1.3

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in nervous system. Orthologous to human LRRC3 (leucine rich repeat containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d0333 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa1581	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa21556	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With lrrc3 Human Ortholog

No data available

Associated With lrrc3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Family	IPR050541	Leucine-rich repeat and transmembrane domain-containing protein
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Additional Resources	Length	Leucine-rich repeat	Leucine-rich repeat and transmembrane domain-containing protein	Leucine-rich repeat domain superfamily	Leucine-rich repeat N-terminal domain	Leucine-rich repeat, typical subtype
UniProtKB:A8WHP9	InterPro	266

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 9

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lrrc3-201 (1) Ensembl	Ensembl		1,198 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-253A1	BX247868	ZFIN Curated Data
Encodes	EST	cssl:d0333	CU468760	Thisse et al., 2008

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001113642 (1)	1198 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX247868 (1)	258322 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A8WHP9 (1)	266 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	LRRC3	21	Ensembl:ENSG00000160233 Gene:81543 HGNC:14965 OMIM:617620	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Lrrc3	10	Ensembl:ENSMUSG00000051652 Gene:237387 MGI:2447899	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Martins, R., Vieira, F.A., Power, D.M. (2014) Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. General and comparative endocrinology. 209:61-73

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