Gene
stat2
- ID
- ZDB-GENE-080321-1
- Name
- signal transducer and activator of transcription 2
- Symbol
- stat2 Nomenclature History
- Previous Names
-
- fj84d07
- wu:fj84d07
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 44 | Alliance | Immunodeficiency 44 | 616636 |
| Pseudo-TORCH syndrome 3 | 618886 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ATI0 | InterPro | 703 | |||||||||||
| UniProtKB:A0A8M1NZ93 | InterPro | 835 | |||||||||||
| UniProtKB:A0A8M6Z7C2 | InterPro | 697 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Zhu, H., Wang, Z., Wang, W., Lu, Y., He, Y.W., Tian, J. (2022) Bacterial Quorum-Sensing Signal DSF Inhibits LPS-Induced Inflammations by Suppressing Toll-like Receptor Signaling and Preventing Lysosome-Mediated Apoptosis in Zebrafish. International Journal of Molecular Sciences. 23(13)
- Gao, X., Yuan, Y.Y., Lin, Q.F., Xu, J.C., Wang, W.Q., Qiao, Y.H., Kang, D.Y., Bai, D., Xin, F., Huang, S.S., Qiu, S.W., Guan, L.P., Su, Y., Wang, G.J., Han, M.Y., Jiang, Y., Liu, H.K., Dai, P. (2018) Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.. Journal of Medical Genetics. 55(5):298-306
- Zheng, M., Lu, J., Zhao, D. (2018) Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Scientific Reports. 8:8083
- Huang, C.J., Chou, C.M., Lien, H.W., Chu, C.Y., Ho, J.Y., Wu, Y., Cheng, C.H. (2017) IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Marine biotechnology (New York, N.Y.). 19(3):310-319
- Zheng, M., Lu, J., Zhao, D. (2017) Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. The Science of the total environment. 622-623:930-941
- Yuan, Y., Zhang, J., Zhou, Q. (2016) Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43:99-102
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I.M., Yzaguirre, A.D., Cai, X., Cortes, M., Maijenburg, M.W., Tober, J., Dzierzak, E., Orkin, S.H., Tan, K., North, T.E., Speck, N.A. (2014) Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28(23):2597-612
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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