Gene
timd4
- ID
- ZDB-GENE-080303-10
- Name
- T cell immunoglobulin and mucin domain containing 4
- Symbol
- timd4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is expressed in brain. Orthologous to human TIMD4 (T cell immunoglobulin and mucin domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d185 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-timd4 | Djannatian et al., 2023 | |
| MO1-timd4 | N/A | Montasser et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222K23 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d185 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122617 (1) | 1424 nt | ||
| Genomic | GenBank:CU463029 (1) | 66900 nt | ||
| Polypeptide | RefSeq:NP_001116089 (1) | 259 aa |
- Djannatian, M., Radha, S., Weikert, U., Safaiyan, S., Wrede, C., Deichsel, C., Kislinger, G., Rhomberg, A., Ruhwedel, T., Campbell, D.S., van Ham, T., Schmid, B., Hegermann, J., Möbius, W., Schifferer, M., Simons, M. (2023) Myelination generates aberrant ultrastructure that is resolved by microglia. The Journal of cell biology. 222(3):
- Erbaba, B., Burhan, Ö.P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M.M., Arslan-Ergül, A. (2020) Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. Neurobiology of aging. 94:164-175
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Montasser, M.E., O'Hare, E.A., Wang, X., Howard, A.D., McFarland, R., Perry, J.A., Ryan, K.A., Rice, K., Jaquish, C.E., Shuldiner, A.R., Miller, M., Mitchell, B.D., Zaghloul, N.A., Chang, Y.C. (2018) An APOO Pseudogene on Chromosome 5q is Associated with LDL-C Levels. Circulation. 138(13):1343-1355
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
- Xu, X.G., Hu, J.F., Ma, J.X., Nie, L., Shao, T., Xiang, L.X., Shao, J.Z. (2016) Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 196(4):1686-99
- Yin, W., Naini, S.M., Chen, G., Hentschel, D.M., Humphreys, B.D., Bonventre, J.V. (2016) Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model. Journal of the American Society of Nephrology : JASN. 27(7):1943-57
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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