Gene
nfasca
- ID
- ZDB-GENE-080229-6
- Name
- neurofascin homolog (chicken) a
- Symbol
- nfasca Nomenclature History
- Previous Names
-
- sc:d0205
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; brain development; and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be active in axon and plasma membrane. Is expressed in nervous system; pancreatic system; and trigeminal placode. Orthologous to human NFASC (neurofascin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d205 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Vagionitis et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017767Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027254Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13971 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21902 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27780 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27781 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31826 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38839 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tum112 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nfasca | Vagionitis et al., 2022 | |
| MO1-nfasca | N/A | Voas et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with central and peripheral motor dysfunction | 618356 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin subtype 2 | Neurofascin, immunoglobulin-like domain | Neurofascin/L1/NrCAM, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PUN4 | InterPro | 1168 | |||||||||||
| UniProtKB:A0A8M9QHH2 | InterPro | 1379 | |||||||||||
| UniProtKB:C0L978 | InterPro | 1369 | |||||||||||
| UniProtKB:A0AB32TWN4 | InterPro | 1178 | |||||||||||
| UniProtKB:A0AB32TXA3 | InterPro | 1377 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfasca-201
(1)
|
Ensembl | 6,288 nt | ||
| mRNA |
nfasca-202
(1)
|
Ensembl | 9,923 nt | ||
| mRNA |
nfasca-203
(1)
|
Ensembl | 4,007 nt | ||
| mRNA |
nfasca-204
(1)
|
Ensembl | 4,110 nt | ||
| mRNA |
nfasca-205
(1)
|
Ensembl | 4,066 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-158N23 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d205 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145767 (1) | 4110 nt | ||
| Genomic | GenBank:CR354444 (2) | 218819 nt | ||
| Polypeptide | UniProtKB:A0AB32U331 (1) | 1391 aa |
- Vagionitis, S., Auer, F., Xiao, Y., Almeida, R.G., Lyons, D.A., Czopka, T. (2022) Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo. Cell Reports. 38:110366
- Yang, S., Emelyanov, A., You, M.S., Sin, M., Korzh, V. (2020) Camel regulates development of the brain ventricular system. Cell and tissue research. 383(2):835-852
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
- Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Voas, M.G., Glenn, T.D., Raphael, A.R., and Talbot, W.S. (2009) Schwann Cells Inhibit Ectopic Clustering of Axonal Sodium Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(46):14408-14414
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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