Gene

dmgdh

ID
ZDB-GENE-080227-8
Name
dimethylglycine dehydrogenase
Symbol
dmgdh Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dmgdh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dimethylglycine dehydrogenase deficiency Alliance Dimethylglycine dehydrogenase deficiency 605850
Associated With dmgdh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006076 FAD dependent oxidoreductase
Domain IPR006222 Aminomethyltransferase, folate-binding domain
Domain IPR013977 Aminomethyltransferase, C-terminal domain
Domain IPR032503 FAD dependent oxidoreductase, central domain
Family IPR028896 Aminomethyltransferase-like
Homologous_superfamily IPR027266 GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Homologous_superfamily IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Aminomethyltransferase, C-terminal domain Aminomethyltransferase, folate-binding domain Aminomethyltransferase-like FAD dependent oxidoreductase FAD dependent oxidoreductase, central domain FAD/NAD(P)-binding domain superfamily Glycine cleavage T-protein/YgfZ, C-terminal GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
UniProtKB:A0AB32TAW6 InterPro 900
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dmgdh-201 (1) Ensembl 2,586 nt
mRNA dmgdh-202 (1) Ensembl 1,845 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations