Gene
dmgdh
- ID
- ZDB-GENE-080227-8
- Name
- dimethylglycine dehydrogenase
- Symbol
- dmgdh Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dimethylglycine dehydrogenase deficiency | Alliance | Dimethylglycine dehydrogenase deficiency | 605850 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006076 | FAD dependent oxidoreductase |
| Domain | IPR006222 | Aminomethyltransferase, folate-binding domain |
| Domain | IPR013977 | Aminomethyltransferase, C-terminal domain |
| Domain | IPR032503 | FAD dependent oxidoreductase, central domain |
| Family | IPR028896 | Aminomethyltransferase-like |
| Homologous_superfamily | IPR027266 | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
| Homologous_superfamily | IPR029043 | Glycine cleavage T-protein/YgfZ, C-terminal |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminomethyltransferase, C-terminal domain | Aminomethyltransferase, folate-binding domain | Aminomethyltransferase-like | FAD dependent oxidoreductase | FAD dependent oxidoreductase, central domain | FAD/NAD(P)-binding domain superfamily | Glycine cleavage T-protein/YgfZ, C-terminal | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TAW6 | InterPro | 900 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available