Gene
sc:d0202
- ID
- ZDB-GENE-080226-9
- Name
- sc:d0202
- Symbol
- sc:d0202 Nomenclature History
- Previous Names
-
- icam1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1) and ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d202 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20123 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003987 | Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Intercellular adhesion molecule, N-terminal | Intercellular adhesion molecule/vascular cell adhesion molecule | Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32THW5 | InterPro | 302 | |||||||||
| UniProtKB:X1WFG6 | InterPro | 292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sc:d0202-201
(1)
|
Ensembl | 1,387 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-66E2 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d202 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098252 (1) | 1385 nt | ||
| Genomic | GenBank:CR354432 (1) | 193960 nt | ||
| Polypeptide | UniProtKB:A0AB32THW5 (1) | 302 aa |
No data available
- Ranjan, G., Sehgal, P., Scaria, V., Sivasubbu, S. (2024) SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. EMBO reports. 25(11):4950-4978
- Zhang, Y., Peng, X., Xue, M., Liu, J., Shang, G., Jiang, M., Chen, D., Liu, B., Wang, Y., Jia, X., Xu, J., Zhang, F., Hu, Y. (2023) SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. Biogerontology. 24(5):813-827
- Roca, F.J., Mulero, I., López-Muñoz, A., Sepulcre, M.P., Renshaw, S.A., Meseguer, J., and Mulero, V. (2008) Evolution of the Inflammatory Response in Vertebrates: Fish TNF-{alpha} Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 181(7):5071-5081
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