Gene
prkg1b
- ID
- ZDB-GENE-080225-40
- Name
- protein kinase cGMP-dependent 1b
- Symbol
- prkg1b Nomenclature History
- Previous Names
-
- im:7159478
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Is expressed in several structures, including female organism; heart; integument; nervous system; and pleuroperitoneal region. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159478 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 8 | 615436 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR031831 | cGMP-dependent protein kinase, N-terminal coiled-coil domain |
| Domain | IPR035014 | cGMP-dependent protein kinase, catalytic domain |
| Family | IPR002374 | cGMP-dependent kinase |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | cAMP-dependent protein kinase regulatory subunit | cGMP-dependent kinase | cGMP-dependent protein kinase, catalytic domain | cGMP-dependent protein kinase, N-terminal coiled-coil domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RmlC-like jelly roll fold | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q0L9
|
378 | |||||||||||||
|
UniProtKB:A0A8M9QIZ6
|
342 | |||||||||||||
|
UniProtKB:A0A2R8Q8R8
|
684 | |||||||||||||
|
UniProtKB:F1R125
|
669 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkg1b-201
(1)
|
Ensembl | 2,010 nt | ||
| mRNA |
prkg1b-203
(1)
|
Ensembl | 2,072 nt | ||
| mRNA |
prkg1b-204
(1)
|
Ensembl | 2,055 nt | ||
| mRNA |
prkg1b-205
(1)
|
Ensembl | 1,923 nt | ||
| ncRNA |
prkg1b-002
(1)
|
Ensembl | 942 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance