Gene

itga8

ID
ZDB-GENE-080220-48
Name
integrin, alpha 8
Symbol
itga8 Nomenclature History
Previous Names
  • zgc:172265
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Involved in cilium assembly and embryonic viscerocranium morphogenesis. Predicted to localize to integrin complex. Is expressed in hair cell; head; inner ear; neuromast hair cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itga8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal agenesis Alliance Renal hypodysplasia/aplasia 1 191830
Associated With itga8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain IPR013649 Integrin alpha-2
Family IPR000413 Integrin alpha chain
Homologous_superfamily IPR028994 Integrin alpha, N-terminal
Homologous_superfamily IPR032695 Integrin domain superfamily
Repeat IPR013517 FG-GAP repeat
Repeat IPR013519 Integrin alpha beta-propellor
Domain Details Per Protein
Protein Length FG-GAP repeat Integrin alpha-2 Integrin alpha beta-propellor Integrin alpha chain Integrin alpha chain, C-terminal cytoplasmic region, conserved site Integrin alpha, N-terminal Integrin domain superfamily
UniProtKB:E7F7L7 1059
UniProtKB:E9QIZ0 517
UniProtKB:A8WG89 397
UniProtKB:A0A023GU65 866
UniProtKB:A0A023GU64 1059
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations