Gene
itga8
- ID
- ZDB-GENE-080220-48
- Name
- integrin, alpha 8
- Symbol
- itga8 Nomenclature History
- Previous Names
-
- zgc:172265
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within cilium assembly and embryonic viscerocranium morphogenesis. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Is expressed in hair cell; head; inner ear; neuromast hair cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal agenesis | Alliance | Renal hypodysplasia/aplasia 1 | 191830 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PK29
|
1059 |
Interactions and Pathways
No data available
Plasmids
No data available