kcnq2a

ID

ZDB-GENE-080220-37

Name

potassium voltage-gated channel, KQT-like subfamily, member 2a

Symbol

kcnq2a Nomenclature History

Previous Names

zgc:171872

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in central nervous system; heart; and inner ear. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnq2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
benign neonatal seizures	Alliance	Myokymia	121200
benign neonatal seizures	Alliance	Seizures, benign neonatal, 1	121200
developmental and epileptic encephalopathy 7	Alliance	Developmental and epileptic encephalopathy 7	613720

Associated With kcnq2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Family	IPR003937	Potassium channel, voltage dependent, KCNQ
Family	IPR003947	Potassium channel, voltage dependent, KCNQ2