Gene
cblc
- ID
- ZDB-GENE-080220-20
- Name
- Cbl proto-oncogene C, E3 ubiquitin protein ligase
- Symbol
- cblc Nomenclature History
- Previous Names
-
- si:ch211-175g6.9
- zgc:172162 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Orthologous to human CBLC (Cbl proto-oncogene C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR003153 | Adaptor protein Cbl, N-terminal helical |
| Domain | IPR014741 | Adaptor protein Cbl, EF hand-like |
| Domain | IPR014742 | Adaptor protein Cbl, SH2-like domain |
| Domain | IPR024159 | Adaptor protein Cbl, PTB domain |
| Family | IPR024162 | Adaptor protein Cbl |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036537 | Adaptor protein Cbl, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Adaptor protein Cbl | Adaptor protein Cbl, EF hand-like | Adaptor protein Cbl, N-terminal domain superfamily | Adaptor protein Cbl, N-terminal helical | Adaptor protein Cbl, PTB domain | Adaptor protein Cbl, SH2-like domain | EF-hand domain pair | SH2 domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9JRD3
|
499 | |||||||||||
|
UniProtKB:A0A8M9PD63
|
591 | |||||||||||
|
UniProtKB:A0A8M9PMJ3
|
590 | |||||||||||
|
UniProtKB:F6PCP5
|
502 |
Interactions and Pathways
No data available
Plasmids
No data available