Gene

rapgef4b

ID

ZDB-GENE-080219-4

Name

Rap guanine nucleotide exchange factor 4b

Symbol

rapgef4b Nomenclature History

Previous Names

si:ch211-114n24.2
zgc:171558

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rapgef4b Human Ortholog

No data available

Associated With rapgef4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000591	DEP domain
Domain	IPR000595	Cyclic nucleotide-binding domain
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	DEP domain	RmlC-like jelly roll fold	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:A8WFT8 InterPro	427

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rapgef4-203 (1) Ensembl	Ensembl	2,184 nt	Select Tool ZFIN BLAST
mRNA	zgc:171558-203 (1) Ensembl	Ensembl	5,912 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000061490 (1) Ensembl	Ensembl	534 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations