Gene

mapk8a

ID

ZDB-GENE-080218-17

Name

mitogen-activated protein kinase 8a

Symbol

mapk8a Nomenclature History

Previous Names

jnk1a (1)
jnk1a-2 (1)
zgc:172209

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable JUN kinase activity. Acts upstream of or within enteric nervous system development. Predicted to be active in cytoplasm and nucleus. Is expressed in atrium; cardiac ventricle; heart; and heart tube. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk8a Human Ortholog

No data available

Associated With mapk8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Conserved_site	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
Domain	IPR000719	Protein kinase domain
Family	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Mitogen-activated protein (MAP) kinase, conserved site	Mitogen-activated protein (MAP) kinase, JNK	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:E9QBW8 InterPro	427
UniProtKB:A0A8M6Z3T6 InterPro	384
UniProtKB:A0A8M6Z2A6 InterPro	421
UniProtKB:A8WG58 InterPro	427

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mapk8a-201 (1) Ensembl	Ensembl	1,618 nt	Select Tool ZFIN BLAST
mRNA	mapk8a-202 (1) Ensembl	Ensembl	2,211 nt	Select Tool ZFIN BLAST
mRNA	mapk8a-204 (1) Ensembl	Ensembl	1,796 nt	Select Tool ZFIN BLAST
mRNA	mapk8a-205 (1) Ensembl	Ensembl	421 nt	Select Tool ZFIN BLAST
mRNA	mapk8a-206 (1) Ensembl	Ensembl	2,254 nt	Select Tool ZFIN BLAST
mRNA	mapk8a-207 (1) Ensembl	Ensembl	2,254 nt	Select Tool ZFIN BLAST
ncRNA	mapk8a-003 (1) Ensembl	Ensembl	746 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations