Gene
mark2b
- ID
- ZDB-GENE-080215-4
- Name
- MAP/microtubule affinity-regulating kinase 2b
- Symbol
- mark2b Nomenclature History
- Previous Names
-
- mark2
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la025900Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9740 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34062 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | KA1 domain/Ssp2, C-terminal | Kinase associated domain 1 (KA1) | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase MARK 1-4, catalytic domain | Ubiquitin-associated domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3B425
|
781 | ||||||||
UniProtKB:A0A8M3BAZ3
|
768 | ||||||||
UniProtKB:A0A8M3AU60
|
741 | ||||||||
UniProtKB:A0A8M3AU67
|
777 | ||||||||
UniProtKB:A0A8M3AU54
|
789 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mark2-201
(1)
|
Ensembl | 539 nt | ||
mRNA |
mark2b-201
(1)
|
Ensembl | 2,343 nt | ||
mRNA |
mark2b-202
(1)
|
Ensembl | 2,304 nt | ||
mRNA |
mark2b-203
(1)
|
Ensembl | 655 nt | ||
mRNA |
mark2b-205
(1)
|
Ensembl | 5,075 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-226L4 | ZFIN Curated Data | |
Contained in | BAC | DKEY-269E10 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009303144 (1) | 5083 nt | ||
Genomic | GenBank:BX511061 (1) | 200880 nt | ||
Polypeptide | UniProtKB:A0A8M3BAY8 (1) | 790 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Burguera, D., Marquez, Y., Racioppi, C., Permanyer, J., Torres-Méndez, A., Esposito, R., Albuixech-Crespo, B., Fanlo, L., D'Agostino, Y., Gohr, A., Navas-Perez, E., Riesgo, A., Cuomo, C., Benvenuto, G., Christiaen, L.A., Martí, E., D'Aniello, S., Spagnuolo, A., Ristoratore, F., Arnone, M.I., Garcia-Fernàndez, J., Irimia, M. (2017) Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Nature communications. 8:1799
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Rakshambikai, R., Srinivasan, N., and Gadkari, R.A. (2014) Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Journal of Bioinformatics and Computational Biology. 12(1):1350014
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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