ZFIN is now using GRCz12tu for Genomic Data
Gene
cox18
- ID
- ZDB-GENE-080204-88
- Name
- cytochrome c oxidase assembly factor COX18
- Symbol
- cox18 Nomenclature History
- Previous Names
-
- zgc:174864
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial respiratory chain complex IV assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2 and cytochrome-c oxidase deficiency disease. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-tooth disease axonal type 2MM | Alliance | Charcot-Marie-Tooth disease, axonal, type 2MM | 621488 |
| ?Mitochondrial complex IV deficiency, nuclear type 25 | 621487 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Membrane insertase YidC/ALB3/OXA1/COX18 | Membrane insertase YidC/Oxa/ALB, C-terminal |
|---|---|---|---|---|
| UniProtKB:A0A8M3AGY1 | InterPro | 326 | ||
| UniProtKB:A0A8M9PZ05 | InterPro | 332 | ||
| UniProtKB:A9JTC7 | InterPro | 328 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers