Gene
marchf8
- ID
- ZDB-GENE-080204-8
- Name
- membrane-associated ring finger (C3HC4) 8
- Symbol
- marchf8 Nomenclature History
- Previous Names
-
- march8
- zgc:171495
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable MHC protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within negative regulation of defense response to virus and protein ubiquitination. Predicted to be located in cytoplasmic vesicle and lysosomal membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Is expressed in blastomere and brain. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kim et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger, RING-CH-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3B555 | InterPro | 281 | |||
| UniProtKB:A0A8M3B7Y1 | InterPro | 303 | |||
| UniProtKB:B8A530 | InterPro | 282 | |||
| UniProtKB:A0A8M3AZ09 | InterPro | 564 | |||
| UniProtKB:A0A8M1P379 | InterPro | 580 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
march8-201
(1)
|
Ensembl | 1,439 nt | ||
| mRNA |
march8-202
(1)
|
Ensembl | 891 nt | ||
| mRNA |
march8-204
(1)
|
Ensembl | 977 nt | ||
| mRNA |
march8-206
(1)
|
Ensembl | 5,502 nt | ||
| ncRNA |
march8-003
(1)
|
Ensembl | 732 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-214N2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-27M7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-74C10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171495 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327919 (1) | 5670 nt | ||
| Genomic | GenBank:BX470214 (2) | 234545 nt | ||
| Polypeptide | UniProtKB:A0A8M1P379 (1) | 580 aa |
- Xiong, S.T., Ying, Y.R., Long, Z., Li, J.H., Zhang, Y.B., Xiao, T.Y., Zhao, X. (2023) Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. International journal of biological macromolecules. 240:124384
- Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, M.H., Rebbert, M.L., Ro, H., Won, M., Dawid, I.B. (2014) Cell adhesion in zebrafish embryos is modulated by march8. PLoS One. 9:e94873
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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